Heart failure & cardiomyopathies
Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study
Authors' conclusion
Accelerated pacing acutely reduces left-heart filling pressure in patients undergoing AF catheter ablation and computer simulations with HFpEF features
Study context
- Population
- Patients undergoing catheter ablation for atrial fibrillation (AF); virtual heart failure with preserved ejection fraction (HFpEF) cohort (simulations)
- Participants
- 75 consecutive patients
- Comparison
- Accelerated atrial pacing vs sinus rhythm
- Outcome
- Mean left atrial pressure (mLAP) with accelerated atrial pacing in 10 bpm increments up to Wenckebach block
Methodological detailscombined clinical-computational, consecutive patients, computer simulations (CircAdapt)
- Combined clinical-computational
- Consecutive patients
- Computer simulations (CircAdapt)
Main finding
As reported in the abstract
mLAP
Optimal pacing rate vs Sinus rhythm: P < 0.001 · Higher pacing rate vs Sinus rhythm: P < 0.05
Further findings
Cohort characteristics
- High HFpEF likelihood (H2FPEF ≥ 5.0)
- 49(65%)
- Elevated mean left atrial pressure (mLAP) ≥ 15 mmHg at sinus rhythm
- 28(37%)
PR interval (atrioventricular (AV) conduction delay)
- Prolonged incrementally with increasing pacing rates
Computer simulations (virtual HFpEF cohort)
- mLAP reduction at moderately increased pacing rate and subsequent increase at higher rates
- mLAP reduction optimized when AV conduction delay shortens with increasing rate
Original publication
Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. Eur Heart J. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →