Heart failure & cardiomyopathies
Comparison of Physical Frailty Assessments in Heart Failure With Preserved Ejection Fraction
Authors' conclusion
Frailty assessments yield a wide range of prevalence estimates and vary in their associations with clinical outcomes. The CFS, FRAIL scale, and the 5-m gait speed tests demonstrated associations with adverse outcomes
Study context
- Population
- Outpatients with heart failure with preserved ejection fraction (HFpEF), Weill Cornell Medicine, June 2018–August 2022; median age 76.7 years (IQR 69.7–83.9)
- Participants
- 203 outpatients
- Exposure
- Six physical frailty assessments compared for prevalence and prognostic value
- Outcome
- Composite of:
- All-cause mortality
- Hospitalization
- Follow-up
- 1 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Frailty vs primary endpoint (multivariate Cox, adjusted for race and MAGGIC score)
Hazard ratio (95% CI)P value
CFS
2.83(1.61–4.98)
P < 0.001FRAIL scale
1.96(1.25–3.07)
P = 0.0045-m gait speed test
2.80(1.50–5.25)
P = 0.001Observational data: associations, not effects.
Further findings
Prevalence of frailty
- Prevalence of frailty: range across the 6 assessments (lowest to highest)
Prevalence of frailty
- Prevalence increased with advancing HFpEF severity
Original publication
Comparison of Physical Frailty Assessments in Heart Failure With Preserved Ejection Fraction. JACC Adv. Published 26 December 2024. doi:10.
Summarised from the published abstract; every number is checked against it