Prevention & lipidsCohort study
Accelerometer-measured circadian alignment predicts all-cause and cardiovascular mortality in middle-aged and older adults
- Prospective cohort study
- NHANES 2011-2014
- weighted Cox regression
- competing risk models
Authors' conclusion
A lower phasor magnitude and both advanced and delayed phasor angles were associated with higher all-cause and CVD-specific mortality.
Study context
- Population
- US adults aged ≥45 years, NHANES 2011–2014, wrist-worn accelerometer
- Participants
- 4,814 adults · 31,280 person-years
- Exposure
- Quartiles of accelerometer-derived phasor magnitude and phasor angle
- Outcome
- All-cause and CVD-specific mortality
- Follow-up
- Through December 31, 2019
Main finding
As reported in the abstract
All-cause and CVD mortality
Hazard ratio (95% CI)
Magnitude Q1 vs Magnitude Q4all-cause mortality
1.70(1.08–2.68)
Angle Q1 vs Angle Q2CVD mortality; 68% increased risk
1.68(1.09–2.60)
- Deaths
- 736
- Cardiovascular disease (CVD) deaths
- 235
Observational data: associations, not effects.
Further findings
Restricted cubic splines
- Nonlinear relationships confirmed
Original publication
Accelerometer-measured circadian alignment predicts all-cause and cardiovascular mortality in middle-aged and older adults. Eur J Prev Cardiol. Published 17 July 2025. doi:10.1093/eurjpc/zwaf445
Summarised from the published abstract; every number is checked against it