Heart failure & cardiomyopathiesTrial design
Acetazolamide effects on natriuresis and diuresis in acute heart failure treated with furosemide and SGLT2i (SANDI)
- prospective, multicentre, observational study
Study context
- Population
- Patients hospitalized with acute heart failure (AHF) and clinical signs of congestion, receiving intravenous loop diuretics and an SGLT2i within the first 24 h of admissionplanned enrolment
- Participants
- 64 patients
- Planned comparison
- Adding acetazolamide to intravenous furosemide and SGLT2i in patients with persistent congestion
- Primary endpoint
- Change in natriuresis
- Follow-up
- Within the first 24 h following acetazolamide administration
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Acetazolamide effects on natriuresis and diuresis in acute heart failure treated with furosemide and SGLT2i (SANDI). ESC Heart Fail. Published 1 April 2026. doi:10.1093/eschf/xvag096
Summarised from the published abstract; every number is checked against it