Heart failure & cardiomyopathies
Determinants of Diuresis/Natriuresis Following Ambulatory Intravenous Loop Diuretics for Worsening Heart Failure
Authors' conclusion
Ambulatory 4-h IV loop diuretic sessions induced a diuresis of approximately 1000 mL with a substantial sodium content, without causing significant complications.
Study context
- Population
- Advanced HF with no therapeutic project and a frequent flyer profile, receiving ambulatory 4-h intravenous (IV) loop diuretic sessions175 IV diuretic sessions
- Participants
- 76 participants
- Outcome
- Factors associated with diuretic response (diuresis and natriuresis) after IV furosemide infusion
- Follow-up
- 4-h session
Main finding
As reported in the abstract
Diuretic response per session
- Mean diuresis
- 1.0 L
- Natriuresis
- 92.6 mmol/L
- Weight loss
- 610 grams
- Baseline ACEi: higher diuresis
- +302 mL, P = 0.0005
- eGFR: higher diuresis per 10 mL/min/1.73 m² increase
- +160 mL, P < 0.0001
- Thiazide added during session: higher diuresis
- +238 mL, P = 0.0001
- Baseline ACEi: higher natriuresis
- +10.83 mmol/L, P = 0.018
Observational data: associations, not effects.
Safety
Worsening renal function (>3 mg/L increase from baseline) and dyskalaemia · 48 h after sessions
- Worsening renal function
- 11%
- Dyskalaemia
- 15%
Original publication
Determinants of Diuresis/Natriuresis Following Ambulatory Intravenous Loop Diuretics for Worsening Heart Failure. ESC Heart Fail. Published 13 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →