Heart failure & cardiomyopathies
Acoustic Features are Independently Associated with Heart Failure and Pulmonary Hypertension
Authors' conclusion
SR is significantly slower in patients with HF alone, PH alone and HF and PH combined compared with patients without disease. CPP also differs significantly in patients with PH compared with controls. These findings suggest that acoustic analysis may be useful in discriminating chronic stable HF and PH, offering promise for the development of non-invasive screening methods for HF and PH.
Study context
- Population
- Patients evaluated for heart failure (HF) and/or pulmonary hypertension (PH) in the outpatient settingpatients included · HF 879 · PH 542 · no disease and no symptoms 777
- Participants
- 2,153 patients
- Comparison
- PH only, HF only and HF with PH compared with no disease
- No diseasen = 777
- Outcome
- Speech rate (SR)
Methodological detailsoutpatient setting, adjusted for age and sex
- Outpatient setting
- Adjusted for age and sex
Main finding
As reported in the abstract
Estimated coefficient
−0.14
95% CI −0.21 to −0.06P = 0.0006
PH only vs no disease · lower in PH only
Estimated coefficient
−0.11
95% CI −0.17 to −0.05P = 0.0002
HF only vs no disease · lower in HF only
Estimated coefficient
−0.17
95% CI −0.24 to −0.10P < 0.0001
HF with PH vs no disease · lower in HF with PH
Further findings
| Outcome | Estimated coefficient (CI) | P value |
|---|---|---|
| CPP-VPH only vs no disease | 0.37 (0.16–0.57) | P = 0.0004 |
| CPP-AllPH only vs no disease | 0.23 (0.08–0.38) | P = 0.0025 |
Baseline characteristics
- Age
- 65.32 ± 17.18 years
- Male
- n = 1246 (57.9%)
- HF
- 879 (40.8%)
- PH
- 542 (25.2%)
- No disease and no symptoms
- 777 (36.1%)
Original publication
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