Heart failure & cardiomyopathies
Lower NT-Probnp Plasma Concentrations in Pacific Peoples with Heart Failure
Authors' conclusion
In HF, Pacific and Māori people had significantly lower median plasma concentrations of NT-proBNP than NZ Europeans. This difference remained after adjusting for clinical and demographic factors in patients with Pacific ethnicity. Pacific peoples also had a significantly lower rate of increase of NT-proBNP with age compared with NZ Europeans and Māori.
Study context
- Population
- Patients with heart failure (HF) of Pacific, Māori and NZ European ethnicityPEOPLE 836 · IMPERATIVE-HF 413
- Participants
- 127 / 221 / 901
- Exposure
- NT-proBNP concentrations in Pacific peoples and Māori compared with NZ Europeans
- Pacificn = 127
- Māorin = 221
- NZ Europeansn = 901
- Outcome
- Median NT-proBNP concentration (unadjusted)
Main finding
As reported in the abstract
Pacific vs NZ Europeans: P < 0.001 · Māori vs NZ Europeans: P < 0.001
Observational data: associations, not effects.
Further findings
Predictors of NT-proBNP
- NT-proBNP was independently associated with ethnicity, age, sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF) and presence of atrial fibrillation (AF)
- Significant differences between Pacific peoples, but not Māori, and NZ Europeans remained after adjusting
Effect of age on NT-proBNP by ethnicity
- Effect of age differed significantly between Pacific peoples and NZ Europeans, but not between Māori and NZ European
- P for interaction = 0.0109
- For each decade of life over 60 years, NT-proBNP on average lower in a Pacific person than an aged-matched NZ European
- 67%
Original publication
Lower NT-Probnp Plasma Concentrations in Pacific Peoples with Heart Failure. ESC Heart Fail. Published 28 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it