Acute cardiac care & resuscitation
Acute Cardiac Events in Hospitalized Older Adults With Respiratory Syncytial Virus Infection
Authors' conclusion
In this cross-sectional study over 5 RSV seasons, nearly one-quarter of hospitalized adults aged 50 years or older with RSV infection experienced an acute cardiac event (most frequently acute heart failure), including 1 in 12 adults (8.5%) with no documented underlying cardiovascular disease. The risk of severe outcomes was nearly twice as high in patients with acute cardiac events compared with patients who did not experience an acute cardiac event.
Study context
- Population
- Hospitalized adults aged ≥50 years with laboratory-confirmed respiratory syncytial virus (RSV) infection, 12 US states, 2014–2015 through 2017–2018 and 2022–2023 seasons
- Participants
- 6,248 adults
- Exposure
- Patients with vs without acute cardiac events
- Outcome
- Weighted period prevalence of acute cardiac events; severe outcomes (ICU admission, invasive mechanical ventilation or in-hospital death) with vs without acute cardiac events
- Follow-up
- During hospitalization
Methodological detailssurveillance data (RSV Hospitalization Surveillance Network), 12 states, 5 RSV seasons
- Surveillance data (RSV Hospitalization Surveillance Network)
- 12 states
- 5 RSV seasons
Main finding
As reported in the abstract
- Any acute cardiac event
- 22.4% (95% CI, 21.0%-23.7%)
- Acute HF
- 15.8% (95% CI, 14.6%-17.0%)
- Acute ischemic heart disease
- 7.5% (95% CI, 6.8%-8.3%)
- Hypertensive crisis
- 1.3% (95% CI, 1.0%-1.7%)
- VT
- 1.1% (95% CI, 0.8%-1.4%)
- Cardiogenic shock
- 0.6% (95% CI, 0.4%-0.8%)
Observational data: associations, not effects.
Further findings
| Outcome | Acute cardiac event | No acute cardiac event | ARR (95% CI) | |
|---|---|---|---|---|
| Acute cardiac event, by underlying CVDUnderlying CVDvs No underlying CVD33.0% vs 8.5% | 3.51 (2.85–4.32) | |||
| ICU admission | 25.8% | 16.5% | 1.54 (1.23–1.93) | |
| In-hospital death | 8.1% | 4.0% | 1.77 (1.36–2.31) | |
| 0.20.5125Adjusted relative risk (log scale) |
- Intensive care unit (ICU) admission — ICU admission, all hospitalized adults
- 18.6%
- In-hospital death — In-hospital death, all hospitalized adults
- 4.9%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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