Arrhythmias & electrophysiology
Acute human defibrillation performance of a subcutaneous implantable cardioverter-defibrillator with an additional coil electrode
Authors' conclusion
Adding a second shock coil, particularly in the parallel configuration, significantly reduced the impedance and had a high likelihood of defibrillation success at energies ≤40 J.
Study context
- Population
- Patients receiving a conventional subcutaneous implantable cardioverter-defibrillator (S-ICD) system (success at 65 J required before investigational testing)
- Comparison
- S-ICD with additional coil electrode vs conventional S-ICD
- Paralleln = 33
- Transversen = 20
- Outcome
- Defibrillation efficacy of parallel and transverse configurations
Methodological details2 phases, randomised order of configurations (phase 2)
- 2 phases
- Randomised order of configurations (phase 2)
Main finding
As reported in the abstract
Shock success rate at 20, 30 and 40 J
| Outcome | Parallel | Transverse |
|---|---|---|
| 20 J | 55% | 25% |
| 30 J | 79% | 70% |
| 40 J | 97% | 90% |
Further findings
| Outcome | Parallel | Transverse | Conventional S-ICD | P value |
|---|---|---|---|---|
| Mean shock impedance, parallel vs conventionaln = 33 | mean 69 (SD 15) Ω | — not stated in the abstract | mean 86 (SD 20) Ω | P < 0.001 |
| Mean shock impedance, transverse vs conventionaln = 20 | — not stated in the abstract | mean 56 (SD 14) Ω | mean 81 (SD 21) Ω | P < 0.001 |
— not stated in the abstract
Safety
- Defibrillation threshold testing well tolerated with no serious adverse events
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Acute human defibrillation performance of a subcutaneous implantable cardioverter-defibrillator with an additional coil electrode. Heart Rhythm. Published 12 August 2023. doi:10.
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