Heart failure & cardiomyopathies
Acute Myocarditis According to Age: Presentation, Management and Early Outcomes
Authors' conclusion
AM exhibits variations in presentation, aetiologies and management but has a comparable 30 day prognosis in children and adults. These findings underscore the importance of tailored management strategies in AM across different age groups.
Study context
- Population
- Patients with acute myocarditis, children and adults
- Participants
- 745 acute myocarditis (AM) patients
- Exposure
- Children and adults
- Childrenn = 328
- Adultsn = 417
- Outcome
- Male sex
Methodological details53 paediatric and adult units, March 2020 to November 2021
- 53 paediatric and adult units
- March 2020 to November 2021
Main finding
As reported in the abstract
Mainly male
73.4%
Observational data: associations, not effects.
Further findings
Ventilatory support
| Outcome | Children | Adults |
|---|---|---|
| Multisystem inflammatory syndrome (MIS) | 69.8% | — not stated in the abstract |
| Infectious aetiologies | 13.4 | 52.4% |
| Heart failure | 15.9 | 7.2% |
| Cardiogenic shock | 14.4 | 6.9% |
| Inotropes | 25.0 | 9.4% |
| Vasopressors | 12.0 | 6.2% |
| Corticosteroids | 68.3 | 14.3 |
| Immunomodulators | 65.1 | 4.5% |
| Myocarditis-related events (MRE): all-cause death, cardiogenic shock, cardiac arrest, ventricular arrhythmias or complete AV block · within 30 daysNot significantly different | 18.1 | 13.4% |
— not stated in the abstract
- Heart failure: P < 0.001
- Cardiogenic shock: P < 0.001
- Inotropes: P < 0.001
- Vasopressors: P < 0.001
- Ventilatory support: P = 0.01
- Corticosteroids: P < 0.001
- Immunomodulators: P < 0.001
- Myocarditis-related events (MRE): all-cause death, cardiogenic shock, cardiac arrest, ventricular arrhythmias or complete AV block: P = 0.09
Cardiac treatments
- Cardiac treatments were used less frequently in children
Extra-cardiac manifestations at admission as predictor of MRE
- Adjusted odds ratio
- 2.40 (1.43-4.38)
- Regardless of multisystem inflammatory syndrome (MIS) status
Original publication
Acute Myocarditis According to Age: Presentation, Management and Early Outcomes. ESC Heart Fail. Published 22 May 2025. doi:10.
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