Heart failure & cardiomyopathies
Efficacy of cardiac resynchronization therapy on cardiac sarcoidosis: Insight into mechanism of mechanical response and the role of myocardial work
Authors' conclusion
Patients with CS had poor outcomes after CRT. Baseline MW differences in the lateral-septal wall and improvements in septal MW may play an essential role in improving cardiac function.
Study context
- Population
- Patients with cardiac sarcoidosis (CS) and dilated cardiomyopathy (DCM) who underwent cardiac resynchronization therapy (CRT) implantation and had complete left bundle branch block and QRS width of ≥ 150 ms
- Comparison
- The outcomes and changes in myocardial work (MW) were compared between the groups.
- CSn = Twenty
- DCMn = 73
- Outcome
- Response rate (≥ 15% decrease in left ventricular end-systolic volume after 6 months)
- Follow-up
- 6 months
Main finding
As reported in the abstract
P < 0.001
Further findings
Death and left ventricular assist device implantation
- Higher incidence in the CS group than the DCM group
MW before implantation
- CS group had a higher MW of the septal wall and smaller MW differences in the lateral-septal wall than the DCM group
Change in MW after implantation
- Increase in the septal wall MW significantly lower in the CS group, resulting in a smaller reduction in the lateral-septal wall MW difference
Determinants of left ventricular end-systolic volume reduction
- MW difference in lateral-septal wall and basal septum thinning were determinants
Original publication
Efficacy of cardiac resynchronization therapy on cardiac sarcoidosis: Insight into mechanism of mechanical response and the role of myocardial work. Heart Rhythm. Published 21 May 2025. doi:10.
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