Pulmonary vascular disease & thromboembolism
Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism
Authors' conclusion
Mechanical thrombectomy with the FlowTriever System demonstrates a favourable safety profile, improvements in haemodynamics and functional outcomes, and low 30-day mortality for intermediate- and high-risk PE.
Study context
- Population
- Intermediate- and high-risk pulmonary embolism (PE) (full US cohort)full US cohort
- Participants
- 800 participants
- Outcome
- MAE composite:
- Device-related death and major bleeding at 48 hours
- Intraprocedural adverse events
- Follow-up
- 48 hours
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Major adverse events
1.8%
Observational data: associations, not effects.
Further findings
All-cause mortality · 48 hours and 30 days
- All-cause mortality at 48-hour follow-up
- 0.3%
- All-cause mortality at 30-day follow-up
- 0.8%
- Device-related deaths
- 0
Mean pulmonary artery pressure (immediate)
- Mean drop in mean pulmonary artery pressure, mmHg
- 7.6
- Relative change
- −23.0%; p<0.0001
Cardiac index (immediate; patients with depressed baseline values)
- Mean increase in cardiac index, L/min/m²
- 0.3
- Relative change
- 18.9%; p<0.0001
- In patients with depressed baseline values
No overnight ICU stay post-procedure
- Patients with no overnight ICU stay
- 62.6%
Echocardiographic RV/LV ratio · 48 hours
- RV/LV ratio decreased from 1.23±0.36 to 0.98±0.31
- P < 0.0001
- p for paired values
Severe dyspnoea · 48 hours
- Patients with severe dyspnoea decreased from 66.5% to 15.6%
- P < 0.0001
Safety
Major adverse events (device-related death, major bleeding at 48 h, intraprocedural AEs)
- Major adverse events
- 1.8%
- Device-related deaths
- 0
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →