Valvular & structural heart disease
Adaptation of Right Ventricular Function Following Tricuspid Transcatheter Edge-To-Edge Repair
Authors' conclusion
RV response to T-TEER is heterogeneous, mostly influenced by baseline RV function, RV-PA coupling and TR progression. Only a minority of patients exhibited an increase in RVEF post T-TEER, and these patients showed worsening TR and a poorer prognosis.
Study context
- Population
- Patients with significant tricuspid regurgitation (TR) who underwent tricuspid transcatheter edge-to-edge repair (T-TEER) and cardiac magnetic resonance (CMR) imaging, with follow-up CMR within 1 to 3 months after the proceduremedian age 78 years, 54% female
- Participants
- 69 patients
- Comparison
- Patients classified by postprocedural RV ejection fraction (RVEF) change: decreased, stable or increased
- Decreasedn = 32
- Stablen = 27
- Increasedn = 10
- Outcome
- Composite of:
- All-cause mortality
- Heart failure hospitalization
- Follow-up
- Median 1016 days
Main finding
As reported in the abstract
Event rates were lowest in the stable RVEF group and highest in the increased RVEF group
log-rank P = 0.004
Patients died
16
Hospitalized for heart failure
15
Further findings
Baseline RVEF
Pulmonary artery systolic pressure
| Outcome | Decreased | Stable | Increased |
|---|---|---|---|
| Baseline RV to pulmonary artery coupling | 1.00 | 1.18 | 0.78 |
| Effective RVEF · After T-TEER | 30% to 35% | 31% to 39% | 30% to 20% |
- Baseline RVEF: P = 0.007
- Baseline right ventricular (RV) to pulmonary artery coupling: P = 0.045
- Pulmonary artery systolic pressure: P = 0.048
- Effective RVEF: decreased and stable: both P < 0.001
- Effective RVEF: increased: tended to decline; P = 0.17
TR severity
- Significantly reduced in the decreased and stable RVEF groups
- P < 0.001 for both
- Worsened in the increased RVEF group
- P = 0.037
Original publication
Adaptation of Right Ventricular Function Following Tricuspid Transcatheter Edge-To-Edge Repair. ESC Heart Fail. Published 28 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it