Pulmonary vascular disease & thromboembolism
The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry
Authors' conclusion
Incorporation of echocardiographic parameters improves risk scores in PAH.
Study context
- Population
- Patients with prevalent pulmonary arterial hypertension (PAH) enrolled in the ULTRA RIGHT VALUE study between January 2022 and December 2023patients with prevalent PAH
- Participants
- 401 patients
- Exposure
- European Society of Cardiology (ESC)/European Respiratory Society (ERS) and REVEAL 2.0 risk scores with vs without echocardiographic right ventricle (RV) variables
Methodological detailsmachine learning
- Machine learning
Main finding
As reported in the abstract
Odds of achieving/maintaining a low-risk status per one-unit decrease in any RV morphological parameter
ESC/ERS score: odds increased up to
69%
REVEAL score: odds increased up to
92%
Observational data: associations, not effects.
Further findings
| Outcome | C-index (95% CI) | P value |
|---|---|---|
| C-index for morbi-mortality prediction — ESC/ERS score with echocardiographic variables vs ESC/ERS score · improved from 0.73 (95% CI 0.69-0.76) | 0.78 (0.75–0.81) | P < 0.01 |
| C-index for morbi-mortality prediction — REVEAL 2.0 score with echocardiographic variables vs REVEAL 2.0 score · improved from 0.74 (95% CI 0.67-0.83) | 0.79 (0.76–0.82) | P < 0.01 |
Odds of achieving/maintaining a low-risk status per one-unit increase in any RV functional parameter
- ESC/ERS score: odds increased up to
- 1.28
- REVEAL score: odds increased up to
- 1.78
- Echocardiographic assessments of RV-PA coupling were the most performant
C-index for morbi-mortality prediction
- Machine learning: indexes of RV-PA coupling had the highest influence on the c-index
Original publication
The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry. Eur Heart J Cardiovasc Imaging. Published 17 September 2026. doi:10.
Summarised from the published abstract; every number is checked against it