Pulmonary vascular disease & thromboembolism
Fatty Acid and Oxylipin Metabolism Differentiate Isolated Postcapillary From Combined Pre- and Postcapillary Pulmonary Hypertension
Authors' conclusion
Cpc-PH exhibits a distinct, PAH-like metabolomic signature characterized by higher polyunsaturated fatty acids and fatty acyl esters of hydroxy fatty acids and lower pro-resolvin/vasodilatory oxylipins compared with isolated postcapillary PH. These findings have implications for PH classification, may inform diagnostic strategies, and nominate lipid pathways for therapeutic targeting.
Study context
- Population
- Patients with isolated postcapillary pulmonary hypertension (PH), Cpc-PH, or pulmonary arterial hypertension (PAH), as well as plasma samples from animal models of severe PH
- Participants
- 128 patients
- Exposure
- Cpc-PH vs isolated postcapillary PH, and Cpc-PH vs PAH
- Isolated postcapillary PHn = 21
- Cpc-PHn = 69
- PAHn = 38
- Outcome
- Metabolites differing between Cpc-PH and isolated postcapillary PH
Main finding
As reported in the abstract
Profiled metabolites
844
Differed between Cpc-PH and isolated postcapillary PH
158
Of those, higher in Cpc-PH, particularly polyunsaturated fatty acid and fatty acyl esters of hydroxy fatty acid pathways
28
Of these 28, did not differ from PAH (PAH-like bioactive lipid signature)
24
Observational data: associations, not effects.
Further findings
Mortality
- Adrenic acid, linoleic acid, docosatrienoic acid, palmitoleic acid, and fatty acyl esters of hydroxy fatty acids associated with increased mortality
Su/Hx rat model of PAH
- A subset of Cpc-PH-elevated metabolites was similarly increased
Original publication
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