Heart failure & cardiomyopathies
Adherence to Heart Failure Treatment in Patients with Peripartum Cardiomyopathy
Authors' conclusion
Adherence to HF therapy was associated with favourable LV reverse remodelling in PPCM and better self-rated health status.
Study context
- Population
- Women with peripartum cardiomyopathy (PPCM)
- Participants
- 36 consecutive women
- Exposure
- Adherent vs partially adherent vs non-adherent to HF therapy
- Outcome
- Drug adherence to HF therapy and its association with left ventricular (LV) recovery, functional status and psychological well-being
- Follow-up
- Adherence visit, median 16 months [IQR 5-45] after PPCM diagnosis
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Adherence to HF therapy
- Collected all pharmacy refills in the 6 months prior to adherence visit
- 63.9%
Observational data: associations, not effects.
Further findings
Median
| Outcome | Adherent | Partially adherent | Non-adherent |
|---|---|---|---|
| Overall EQ-5D score (lower = better self-rated health) | 5.5 (IQR 5–7.5) | 6 (IQR 5–7) | 10 (IQR 8–15) |
- LVEDD at follow-up: Adherence median 47 (IQR 46–52) mm
- LVEDD at follow-up: Partial adherence median 56 (IQR 49–64) mm
- LVEDD at follow-up: Non-adherence median 62 (IQR 55–64) mm
- LVEDD at follow-up: P = 0.022
- LVEF at follow-up: Adherence median 60 (IQR 41–65) %
- LVEF at follow-up: Partial adherence median 46 (IQR 34–50) %
- LVEF at follow-up: Non-adherence median 41.0 (IQR 29–47) %
- LVEF at follow-up: P = 014 (as printed)
- Overall EQ-5D score (lower = better self-rated health): P = 0.032
Original publication
Adherence to Heart Failure Treatment in Patients with Peripartum Cardiomyopathy. ESC Heart Fail. Published 4 March 2024. doi:10.
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