Adiposity and Muscle Strength in Men With Prostate Cancer and Cardiovascular Outcomes
Authors' conclusion
ADT was associated with increased adiposity and reduced strength over 12-month follow-up. High waist circumference and low baseline strength were associated with future adverse cardiovascular outcomes.
Study context
- Population
- Patients with prostate cancer diagnosed in the prior 12 months or treated with androgen deprivation therapy (ADT) for the first time1,731 (43.6%) exposed to ADT
- Participants
- 3,967 patients
- Exposure
- Measures of adiposity and strength and CV outcomes
- Outcome
- Cardiovascular outcomes (cardiovascular death, myocardial infarction, stroke, heart failure, arterial revascularization, peripheral arterial disease, and venous thromboembolism) in relation to measures of adiposity and strength
Methodological detailsinternational
- International
Main finding
As reported in the abstract
Future CV event (adjusted)
Hazard ratio (95% CI)P value
Waist circumference >110 cm
1.40(1.03–1.90)
P = 0.029Handgrip strength <29.5 kg
1.59(1.14–2.22)
P = 0.006Observational data: associations, not effects.
Secondary outcomes
Changes in physical measures with ADT · 12 months
- Weight increase
- 1.6%
- Waist circumference increase
- 2.2%
- Hip circumference increase
- 1.6%
- Waist-to-hip ratio increase
- 0.1%
- Handgrip strength reduction
- 27.4%
- Gait speed decrease
- 0.1%
Original publication
Adiposity and Muscle Strength in Men With Prostate Cancer and Cardiovascular Outcomes. JACC CardioOncol. Published 3 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it