Admission Total Leukocyte Count as a Predictor of Mortality in Cardiac Intensive Care Unit Patients

Smith, RJ; Sarma, D; Padkins, MR; Gajic, O; Lawler, PR; Van Diepen, S; Kashani, KB; Jentzer, JC

doi:10.1016/j.jacadv.2023.100757

Acute cardiac care & resuscitation

Admission Total Leukocyte Count as a Predictor of Mortality in Cardiac Intensive Care Unit Patients

JACC AdvPublished 8 Dec 2023Retrospective cohort study

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Authors' conclusion

Leukocytosis is associated with an increased mortality risk in a diverse cohort of CICU patients.

Study context

Population: Patients admitted to the Mayo Clinic Cardiac Intensive Care Unit (CICU), 2007–2018median age 69.3 years
Participants: 11,699 patients

Exposure: WBC categories
Outcome: In-hospital mortality

Methodological detailssingle-centre

Single-centre

Main finding

As reported in the abstract

Low WBC10.5%

Normal WBC5.3%

High WBC12.0%

Very high WBC33.3%

Each group vs normal WBCAICc adjusted OR (95% CI)

High WBC

1.37(1.15–1.64)

Very high WBC

1.99(1.47–2.71)

Rising WBC incrementally associated with higher in-hospital mortality after adjustment, AICc adjusted OR per 1 × 103 increase in WBC: 1.03 (95% CI: 1.02-1.04)

Observational data: associations, not effects.

Original publication

Admission Total Leukocyte Count as a Predictor of Mortality in Cardiac Intensive Care Unit Patients. JACC Adv. Published 8 December 2023. doi:10.1016/j.jacadv.2023.100757

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