Adults With Congenital Heart Disease Have an Increased Prevalence of Autoimmunity
Authors' conclusion
ACHD individuals showed a nearly 2-fold increased odds of developing autoimmune conditions, both for systemic and organ-specific autoimmunity, which persisted among those with simple/moderate CHD. In an age-related analysis, the severe CHD group ≥60 years has a similar risk.
Study context
- Population
- Adults in the All of Us nationwide biomedical database, queried in 20242,941 adult congenital heart disease (ACHD) (1.02%)
- Participants
- 287,012 adults
- Comparison
- ACHD vs matched controls
- ACHDn = 2,941
- Outcome
- Autoimmune conditions
Methodological detailsmatched 1:20 for age, race, sex, smoking and obesity, nationwide biomedical database (All of Us)
- Matched 1:20 for age, race, sex, smoking and obesity
- Nationwide biomedical database (All of Us)
Main finding
As reported in the abstract
Autoimmunity
Odds ratio
1.95
P < 0.05
any autoimmunity
Odds ratio
1.94
P < 0.05
systemic
Odds ratio
1.54
P < 0.05
organ specific
Observational data: associations, not effects.
Further findings
Autoimmunity by congenital heart disease (CHD) severity (subgroup)
| OR | P value | |
|---|---|---|
| Mild CHDn = 1169 | 1.93 | P < 0.05 |
| Moderate CHDn = 703 | 1.56 | P < 0.05 |
| Severe CHDn = 162 | 1.45 | P = 0.168 |
| Outcome | OR | P value |
|---|---|---|
| Systemic and organ-specific autoimmunityACHD vs Controls · systemic | 1.94 | P < 0.05 |
| Systemic and organ-specific autoimmunityACHD vs Controls · organ specific | 1.54 | P < 0.05 |
| Autoimmunity in severe ACHD ≥60 years (age subgroup) | 2.71 | P < 0.05 |
- Autoimmunity by CHD severity (subgroup): 69% classifiable by severity
Original publication
Adults With Congenital Heart Disease Have an Increased Prevalence of Autoimmunity. JACC Adv. Published 7 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →