Heart failure & cardiomyopathies
Adverse Outcomes Associated With Interleukin-6 in Patients Recently Hospitalized for Heart Failure With Preserved Ejection Fraction
Authors' conclusion
In patients recently hospitalized with heart failure with preserved ejection fraction, IL-6 is an independent predictor of all-cause mortality, cardiovascular death, and sHFH after adjustment for risk factors including BNP.
Study context
- Population
- Patients recently hospitalized with HFpEF
- Participants
- 286 participants
- Exposure
- IL-6 tertiles
- Outcome
- All-cause death, CV death and subsequent HF hospitalization (sHFH)
Main finding
As reported in the abstract
All-cause death, CV death, sHFH per log unit increase in IL-6 (adjusted)
IL-6, per log unit increaseHazard ratio (CI)
All-cause death; adjusted
1.46(1.17–1.81)
CV death; adjusted
1.40(1.10–1.77)
sHFH; adjusted
1.24(1.01–1.51)
Per log unit increase, as printed
- All-cause and CV death rates remained higher in T3 vs T1 after adjustment
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | T1 | T3 |
|---|---|---|
| Characteristics, T3 vs T1Value = male | 35% | 56% |
| Creatinine | 101±36 μmol/L | 117±45 μmol/L |
| hsCRP | 2.3[1.1-4.2] mg/L | 11.6 [4.9-26.6]mg/L |
hsCRP per log unit increase
- Associated with higher risk of CV death and all-cause death before and after adjustment; not associated with subsequent heart failure hospitalization (sHFH)
Original publication
Adverse Outcomes Associated With Interleukin-6 in Patients Recently Hospitalized for Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. Published 10 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →