Heart failure & cardiomyopathies
Long-Term Outcomes in Heart Failure with Preserved Ejection Fraction: Predictors of Cardiac and Non-Cardiac Mortality
Authors' conclusion
In patients with acute decompensated HFpEF, over 5 years of follow-up, nearly two-thirds of patients died, half from CV and the other half from non-CV causes. CAD and tricuspid regurgitation were associated with CV death. Stroke, kidney disease, lower BMI, and lower sodium were associated with non-CV death. Anaemia and higher age were associated with both outcomes.
Study context
- Population
- Patients with acute heart failure (HF), EF ≥ 45% and NT-proBNP > 300 ng/L (Karolinska-Rennes study, 2007–11)397 available for long-term follow-up
- Participants
- 539 patients
- Outcome
- Incidence and predictors of long-term CV and non-CV death
- Follow-up
- Median 5.4 (2.1-7.9) years
Methodological detailslong-term follow-up
- Long-term follow-up
Main finding
As reported in the abstract
Long-term mortality · median 5.4 years
- All-cause death
- 269 (68%)
- Cardiovascular (CV) death
- 128 (47%)
- Non-CV death
- 120 (45%)
- CV death incidence rate per 1000 patient-years
- 62 (95% CI 52-74)
- Non-CV death incidence rate per 1000 patient-years
- 58 (95% CI 48-69)
Observational data: associations, not effects.
Further findings
Predictors of CV and non-CV death from baseline acute presentation
- Independent predictors of CV death: higher age, coronary artery disease (CAD)
- Independent predictors of non-CV death: anaemia, stroke, kidney disease, lower body mass index (BMI) and sodium
Predictors of CV and non-CV death from stable 4-8 week visit
- Independent predictors of CV death: anaemia, CAD, tricuspid regurgitation (>3.1 m/s)
- Independent predictor of non-CV death: higher age
Original publication
Long-Term Outcomes in Heart Failure with Preserved Ejection Fraction: Predictors of Cardiac and Non-Cardiac Mortality. ESC Heart Fail. Published 10 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →