Arrhythmias & electrophysiology
Antithrombotic therapy for stable coronary artery disease and atrial fibrillation in patients with and without revascularisation: the AFIRE trial
Authors' conclusion
In high-risk thrombosis patients with a history of prior revascularisation, rivaroxaban monotherapy versus combination therapy demonstrated favourable safety and efficacy outcomes.
Study context
- Population
- Patients with AF and stable CAD, with or without prior revascularisation1,697 with prior revascularisation · with 1,697 · or without 518
- Participants
- 2,215 patients
- Comparison
- Rivaroxaban monotherapy vs combination therapy (rivaroxaban plus a single antiplatelet), by prior revascularisation
- Primary endpoint
- Efficacy: composite of stroke, systemic embolism, MI, unstable angina requiring revascularisation, or all-cause death; safety: major bleeding
Primary result
As reported in the abstract
Primary efficacy (composite of stroke, systemic embolism, MI, unstable angina requiring revascularisation or all-cause death) and primary safety (major bleeding) endpoints, by prior revascularisation
Monotherapy vs Combination therapyHazard ratio (95% CI)P value
Efficacy; prior revascularisation (n=1,697)
0.62(0.45–0.85)
P = 0.003Safety (major bleeding); prior revascularisation (n=1,697)
0.62(0.39–0.98)
P = 0.042- No prior revascularisation (n=518): no significant difference in efficacy endpoint (HR 1.19, 95% CI 0.67-2.12)
- P = 0.554
- No prior revascularisation (n=518): no significant difference in safety endpoint (HR 0.47, 95% CI 0.18-1.26)
- P = 0.134
Safety
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Any bleeding, no prior revascularisation | 0.59 (0.38–0.93) | P = 0.022 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Antithrombotic therapy for stable coronary artery disease and atrial fibrillation in patients with and without revascularisation: the AFIRE trial. EuroIntervention. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →