Arrhythmias & electrophysiology
Long-term reliability of the phospholamban (PLN) p.(Arg14del) risk model in predicting major ventricular arrhythmia: a landmark study
Authors' conclusion
The PLN p.(Arg14del) risk model has sustained good model performance up to 3 years follow-up in PLN p.(Arg14del)-positive subjects with no history of major VA.
Study context
- Population
- PLN p.(Arg14del)-positive individuals with no prior major ventricular arrhythmia (VA) at the 3-year landmark
- Participants
- 268 participants
- Outcome
- Diagnostic performance of the PLN p.(Arg14del) risk model for major VA (sustained VA, appropriate implantable cardioverter defibrillator (ICD) intervention or (aborted) SCD)
- Follow-up
- 3-year follow-up
Methodological detailslandmark analysis
- Landmark analysis
Performance
As reported in the abstract
Risk model performance in the 3-year landmark cohort
C-statistic
0.83
95% CI 0.79–0.87
Calibration slope
0.97
Further findings
Major VA after the 3-year landmark · mean follow-up 4.0 years (± 3.5 years)
- Subjects with major VA
- 28 (10%)
- Annual event rate
- 2.6% (95% CI 1.6-3.6)
Original publication
Long-term reliability of the phospholamban (PLN) p.(Arg14del) risk model in predicting major ventricular arrhythmia: a landmark study. Europace. Published 1 April 2024. doi:10.
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