Heart failure & cardiomyopathies
Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis: Insights From THAOS
Authors' conclusion
In this THAOS analysis of patients with ATTRwt amyloidosis, patients were diagnosed an average of 2 years after symptom onset, with the greatest diagnostic delay in women aged <70 years at 5 years. Patients were predominantly men, but the proportion of women increased with age. A substantial proportion of patients had significant functional impairment regardless of age.
Study context
- Population
- Patients with wild-type transthyretin amyloidosis (ATTRwt) enrolled in THAOS
- Participants
- 1,251 patients
- Exposure
- Age groups and sex
- Outcome
- Age distribution, proportion of women, time from symptom onset to diagnosis, Karnofsky Performance Status ≤70
- Follow-up
- Enrollment
Methodological detailsTHAOS, global, analysis at enrollment, Data cutoff August 1, 2022
- THAOS
- Global
- Analysis at enrollment
- Data cutoff August 1, 2022
Main finding
As reported in the abstract
Age distribution, proportion of women, time from symptom onset to diagnosis, Karnofsky Performance Status ≤70 · enrollment
Women <70 years 4.1% · ≥90 years 14.3%
Median time symptom onset to diagnosis overall (male, female) <70 years 1.7 (1.3, 5.2) years · 70 to 79 years 2.0 (2.0, 2.2) years · 80 to 89 years 1.8 (1.9, 0.8) years · ≥90 years 0.7 (0.6, 2.5) years
Karnofsky score ≤70
Observational data: associations, not effects.
Original publication
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