Heart failure & cardiomyopathies
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score
Authors' conclusion
Using the HFpEF-ABA score, rapid and efficient screening for risk of undiagnosed HFpEF can be performed in patients with dyspnea using only age, body mass index and history of atrial fibrillation.
Study context
- Population
- Patients evaluated for heart failure with preserved ejection fraction (HFpEF) (dyspnea), derivation and validation cohortsderivation cohort
- Participants
- 414 patients
- Outcome
- Discrimination (AUC) of the HFpEF-ABA score for HFpEF
Methodological detailsderivation and validation cohorts, international, multicenter validation cohort
- Derivation and validation cohorts
- International, multicenter validation cohort
Performance
As reported in the abstract
Discrimination for HFpEF
| Test or model | AUC, derivation cohort (n = 414) | AUC, international multicenter validation cohort (n = 736) | AUC, unexplained dyspnea cohort (n = 228) | AUC, HF hospitalization-defined HFpEF cohort (n = 456) |
|---|---|---|---|---|
| HFpEF-ABA score | 0.839 (95% CI 0.800-0.877), P < 0.0001 | 0.813 (95% CI 0.779-0.847), P < 0.0001 | 0.840 (95% CI 0.782-0.900), P < 0.0001 | 0.929 (95% CI 0.909-0.948), P < 0.0001 |
HFpEF-ABA score
AUC, derivation cohort (n = 414)0.839 (95% CI 0.800-0.877), P < 0.0001
AUC, international multicenter validation cohort (n = 736)0.813 (95% CI 0.779-0.847), P < 0.0001
AUC, unexplained dyspnea cohort (n = 228)0.840 (95% CI 0.782-0.900), P < 0.0001
AUC, HF hospitalization-defined HFpEF cohort (n = 456)0.929 (95% CI 0.909-0.948), P < 0.0001
Further findings
HF hospitalization or death (Mayo Clinic n = 790; Veteran Affairs n = 3076)
- Model-based probabilities associated with increased risk of HF hospitalization or death
Original publication
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score. Nat Med. Published 12 July 2024. doi:10.
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