Coronary disease & ACSResearch article
Age-specific coronary outcomes in subacute Kawasaki disease
- Multivariable logistic regression analyses
- Restricted cubic splines
- nine 6-month age groups
Authors' conclusion
Coronary outcomes differed substantially across age groups; patients aged 0 to 6 months had the most adverse coronary outcomes. Even without CALs at initial echocardiography, this age group had the highest risk of subsequent CAL development.
Study context
- Population
- Patients with Kawasaki disease (KD) in Japan (2011–2022)patients with KD in Japan (2011–2022)
- Participants
- 129,950 patients
- Comparison
- Age-specific associations using the restricted cubic splines (RCS)-identified reference group
Main finding
As reported in the abstract
Subsequent CAL development among patients without CALs at initial echocardiography · subacute phase
0 to 6-month group
2.8%
Further findings
| Outcome | adjusted odds ratio (95% CI) | |
|---|---|---|
| CA dilatation regression · less likely with 0 to 6 months · multivariable analysis | 0.44 (0.30–0.63) | |
| CAL progression · more likely with 0 to 6 months · multivariable analysis | 3.84 (3.03–4.86) | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | 0 to 6-month group | 25 to 30-month group | Estimate |
|---|---|---|---|
| CA regression among patients with CA dilatation · subacute phase | 75.5% | Not reported in the abstract |
- Coronary artery (CA) regression among patients with CA dilatation: lowest proportion among age groups; among patients with CA dilatation
CA dilatation regression and CAL progression by age (RCS)
- 25 to 30-month group most likely to show CA dilatation regression and least likely to experience CAL progression
Original publication
Age-specific coronary outcomes in subacute Kawasaki disease. Am Heart J. Published 30 August 2026. doi:10.1016/j.ahj.2026.107593
Summarised from the published abstract; every number is checked against it