Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial
Authors' conclusion
In patients with acute MI and anemia, centralized troponin review identified more than half of all recurrent MI events. Patients with centrally identified MI had a higher risk of cardiac death than those with no recurrent MI.
Study context
- Population
- Patients with acute myocardial infarction (MI) and anemiapatients in the MINT trial
- Participants
- 3,504 patients
- Comparison
- Differences in cardiac, noncardiac, and all-cause death at 30 and 180 days were compared across patients with any site-reported MI, only centrally identified MI, and no recurrent MI.
- site-reported MIn = 119
- only centrally identified MIn = 156
Methodological detailsrandomized to a liberal vs restrictive red blood cell transfusion strategy, centralized review of troponin levels collected for 3 days following randomization
- Randomized to a liberal vs restrictive red blood cell transfusion strategy
- Centralized review of troponin levels collected for 3 days following randomization
Primary result
As reported in the abstract
Recurrent MI · within 30 days
Recurrent MI, of 3,504 patients
275
7.8%
By site-report, of the 275 recurrent MIs
119
43.3%
By central troponin review only, of the 275 recurrent MIs
156
56.7%
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Cardiac death · 30 days and 180 days — only centrally identified MI vs no recurrent MI · 30 days | 1.9 (1.0–3.4) | |
| Cardiac death · 30 days and 180 days — only centrally identified MI vs no recurrent MI · 180 days | 1.7 (1.1–2.7) | |
| 0.20.5125Relative risk (log scale) |
Cardiac, all-cause and noncardiac death · 30 and 180 days
- Rates of cardiac and all-cause death highest for site-reported MI, intermediate for centrally identified MI, and lowest for no recurrent MI
- Rates of noncardiac death did not vary
Original publication
Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial. Am Heart J. Published 9 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it