Heart failure & cardiomyopathies
Age-Stratified Profiles and Outcomes of Patients with Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Younger HFpEF patients (≤64 years) exhibit a male predominance, elevated BMI, and poorly controlled diabetes, highlighting the importance of glycaemic control in reducing SCD risk. Older HFpEF patients (≥65 years) are more likely to be female, with multiple comorbidities linked to an increased risk of HF-related mortality.
Study context
- Population
- Consecutive HFpEF patients (left ventricular ejection fraction (LVEF) ≥ 50%), CHART-2 Study, Tohoku District; mean age 69.0 ± 12.3 years, 67.7% malemedian follow-up 9.8 years
- Participants
- 2,824 patients
- Exposure
- Age groups; younger vs older
- ≤54n = 349
- 55-64n = 529
- 65-74n = 891
- 75-84n = 853
- ≥85n = 202
- Outcome
- Clinical profiles and outcomes across age groups
- Follow-up
- Median 9.8 years
Methodological detailsCHART-2 registry, consecutive patients, age-stratified
- CHART-2 registry
- Consecutive patients
- Age-stratified
Main finding
As reported in the abstract
median follow-up 9.8 years
- With higher age, mortality increased and heart failure (HF) death proportionally more prevalent
- Ptrend < 0.001
- Sudden cardiac death (SCD) proportion showed opposite trend (decreased with higher age)
- Ptrend = 0.002
Observational data: associations, not effects.
Further findings
HF-related mortality in older groups (≥65 years)
- Multiple comorbidities significantly associated with increased risk of HF-related mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Age-Stratified Profiles and Outcomes of Patients with Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 16 April 2024. doi:10.
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