Heart failure & cardiomyopathies
Correlation of extent of left ventricular endocardial unipolar low-voltage zones with ventricular tachycardia in nonischemic cardiomyopathy
Authors' conclusion
In NICM, extent and percentage area of unipolar LVZs are significant predictors of VT. Cutoffs of >3 segments of unipolar LVZ and >33% area of unipolar LVZ have good diagnostic accuracies for association with VT.
Study context
- Population
- Patients with nonischemic cardiomyopathy undergoing LV electroanatomic mapping
- Participants
- 43 patients
- Exposure
- Nonischemic cardiomyopathy (NICM) patients with ventricular tachycardia (VT) vs without VT
- Outcome
- Correlation of bipolar and unipolar EGM characteristics with LVEF and VT
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Global mean unipolar voltage
0.4(0.2–0.8)
Extent of unipolar LVZ
1.6(1.1–2.3)
Percentage area of unipolar LVZ
1.6(1.1–2.3)
- Unipolar electrogram (EGM) variables correlated better with baseline left ventricular ejection fraction (LVEF) than bipolar: unipolar voltage r
- +0.36
- Peak negative unipolar voltage r
- −0.42
- Peak positive unipolar voltage r
- +0.38
- Percentage area of unipolar low-voltage zone (LVZ) r
- −0.41
Observational data: associations, not effects.
Further findings
Classification of patients with VT (diagnostic accuracy)
AUC Extent of unipolar LVZ 0.82 (95% CI, 0.69-0.95; P < .001) · Percentage area of unipolar LVZ 0.83 (95% CI, 0.71-0.96; P = .01)
Cutoff Extent of unipolar LVZ >3 segments · Percentage area of unipolar LVZ 33%
Sensitivity
Specificity
Original publication
Correlation of extent of left ventricular endocardial unipolar low-voltage zones with ventricular tachycardia in nonischemic cardiomyopathy. Heart Rhythm. Published 16 April 2024. doi:10.
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