Albiglutide and atrial fibrillation in patients with Type 2 diabetes and established cardiovascular disease: insights from the Harmony Outcomes trial
Authors' conclusion
In patients with Type 2 diabetes, treatment with albiglutide, compared with placebo, reduced the risk of cardiovascular events irrespective of history of AF. Further, albiglutide treatment did not increase AF adverse events but was associated with a trend to a lower rate of AF events during follow-up without reaching statistical significance.
Study context
- Population
- Patients aged >40 years with T2DM and established CVD8.9% with history of and flutter (AF)
- Participants
- 9,463 patients
- Comparison
- Albiglutide vs placebo, by history of AF
- Primary endpoint
- Primary composite MACE endpoint
- Follow-up
- 1.6 years
Methodological detailsmulticentre, event-driven, double-blind, placebo-controlled
- Multicentre
- Event-driven
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
MACE, by baseline history of AF (subgroups)
Albiglutide vs PlaceboAdjusted hazard ratio (CI)
History of AF
0.83(0.58–1.19)
No history of AF
0.77(0.66–0.90)
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| MACE, history of AFvs no history of AF · 1.6 years of follow-up12.7 vs. 6.3 events/100 person-years | 1.41 (1.14–1.74) | P = 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
Safety
Events
| Outcome | Albiglutide | Placebo | HR (CI) | P value | |
|---|---|---|---|---|---|
| AF events during follow-up | 108 | 131 | 0.82 (0.63–1.06) | P = 0.12 | |
| 0.512Hazard ratio (log scale) |
- AF events during follow-up — Patients with an AF event during follow-up
- 239 (2.5%)
- AF events during follow-up: irrespective of baseline history of AF (Pinteraction = 0.92)
Original publication
Albiglutide and atrial fibrillation in patients with Type 2 diabetes and established cardiovascular disease: insights from the Harmony Outcomes trial. Eur J Prev Cardiol. Published 27 November 2024. doi:10.
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