Misalignment Between Circadian Preference and Accelerometer-Derived Sleep-Wake Cycle With Increased Risk of Cardiometabolic Diseases
Authors' conclusion
Both advanced and delayed circadian misalignment were associated with an increased CMD risk
Study context
- Population
- UK Biobank participants without pre-existing cardiometabolic diseases; misalignment from self-reported chronotype vs accelerometer-derived sleep timing
- Participants
- 60,965 participants
- Exposure
- Circadian misalignment quintiles vs aligned
- Outcome
- Incident cardiometabolic diseases: T2DM, CHD, stroke
- Follow-up
- Mean 7.9 years
Main finding
As reported in the abstract
Each group vs Q3Hazard ratio (95% CI)
Q1T2DM
1.22(1.03–1.45)
Q5T2DM
1.39(1.18–1.62)
Q4CHD
1.15(1.01–1.31)
Q5CHD
1.16(1.02–1.33)
Observational data: associations, not effects.
Further findings
T2DM by chronotype
| HR (95% CI) | ||
|---|---|---|
| Early chronotypeLate chronotype not associated | 1.19 (1.06–1.34) | |
| 0.512Hazard ratio (log scale) |
Delayed misalignment, by sex and age (subgroup)
- Association with T2DM greater in women
- P for interaction = 0.03
- Association with coronary heart disease (CHD) greater in younger adults
- P for interaction = 0.02
Original publication
Misalignment Between Circadian Preference and Accelerometer-Derived Sleep-Wake Cycle With Increased Risk of Cardiometabolic Diseases. JACC Adv. Published 18 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →