Albuminuria linked with interstitial myocardial fibrosis at the population level: the multi-ethnic study of atherosclerosis
Authors' conclusion
Elevated albuminuria levels are related to subclinical fibrosis in a community-based setting, independent of traditional CV risk factors. This association was more prominent among prediabetics, diabetics and among males.
Study context
- Population
- Community-based MESA cohort participants with urine albumin and creatinine measurements and CMR with T1-mapping in 2010 (52% female, mean age 69±9 years)MESA cohort
- Participants
- 2,112 participants
- Exposure
- Albuminuria/ACR vs myocardial fibrosis on CMR T1-mapping
- Outcome
- ECV, native T1 time and myocardial scar on CMR
Methodological detailsmultivariable linear and logistic regression, stratified by sex and diabetes stage
- Multivariable linear and logistic regression
- Stratified by sex and diabetes stage
Main finding
As reported in the abstract
Extracellular volume (ECV) higher, albumin
0.15%
ECV higher, ACR
0.2%
Native T1 time higher, albumin
2.7%
Native T1 time higher, ACR
2.6%
Observational data: associations, not effects.
Further findings
Men: per 1-SD increase in log-transformed albumin and ACR
- ECV higher, albumin and ACR (each)
- 0.3%
- Native T1 time higher, albumin
- 3.3%
- Native T1 time higher, ACR
- 2.6%
Women
- No significant associations with albuminuria or ACR
Prediabetes
- Log-transformed albumin and ACR positively associated with ECV
- P < 0.05
- Not associated with native T1
Diabetes
- Log-transformed albumin: ECV higher
- 0.3%
- Log-transformed albumin: native T1 higher
- 3%
- ACR modest association with ECV and native T1
- p<0.05
Myocardial scar
- Odds of myocardial scar not associated with higher albumin/ACR after adjusting for CV risk factors
Original publication
Albuminuria linked with interstitial myocardial fibrosis at the population level: the multi-ethnic study of atherosclerosis. Eur J Prev Cardiol. Published 9 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →