Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
Authors' conclusion
Elevated Lp(a) levels are linked to greater subclinical IMF, increased myocardial scar prevalence, and left atrial remodeling.
Study context
- Population
- MESA participants with baseline Lp(a) measurements and cardiac magnetic resonance (CMR) (T1 mapping, late gadolinium enhancement, cine) in 20102,826 for remodeling analyses
- Participants
- 2,040 participants
- Exposure
- Higher vs lower Lp levels
- Outcome
- Myocardial fibrosis by CMR (ECV%, native T1 time, myocardial scar) and cardiac remodeling
Methodological detailsMESA cohort
- MESA cohort
Main finding
As reported in the abstract
Odds ratio (95% CI)
Lp(a) per log unitclinically significant IMF, ECV% ≥30%
1.20(1.04–1.43)
Lp(a) per log unitclinically significant IMF, native T1 955 ms
1.2(1.1–1.4)
Lp(a) ≥30 mg/dLmyocardial scar
1.85(1.1–3.2)
Lp(a) ≥50 mg/dLmyocardial scar
1.9(1.1–3.4)
Per log unit, as printed
- Lp(a) per log unit · ECV%
- β 0.2%; P = 0.007
- Lp(a) per log unit · native T1 time
- β 4%; P < 0.001
Observational data: associations, not effects.
Further findings
Left atrial remodeling
- Higher Lp(a) associated with left atrial enlargement and dysfunction
Original publication
Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol. Published 12 December 2023. doi:10.
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