Aortic & peripheral vascular disease
All-cause mortality and death by aortic dissection in women with Turner syndrome: A national clinical cohort study
Main finding · All-cause mortalityResult — go to the resultHazard ratio 2.90 95% CI 1.92–4.37Authors' conclusion
The increased mortality in TS was mainly driven by aortic dissections in the young and by heart diseases in the older.
Study context
- Population
- Women with Turner syndrome recruited from the Turner centers in Sweden, followed since 1995 for up to 26 years
- Participants
- 472 vs 2,357
- Exposure
- Women with turner syndrome (TS) vs matched controls
- TSn = 472
- Controlsn = 2,357reference
- Outcome
- All-cause mortality
- Follow-up
- Mean 17 years
Methodological detailsmatched, national, Cox proportional hazard models; competing risks analysis using cumulative incidence function
- Matched
- National
- Cox proportional hazard models; competing risks analysis using cumulative incidence function
Main finding
As reported in the abstract
Hazard ratio
2.90
95% CI 1.92–4.37
Events by group
TSvs Controls
HR 2.90 (95% CI 1.92–4.37)
Observational data: associations, not effects.
Further findings
| Outcome | HR | |
|---|---|---|
| Death by circulatory diseases | 9.11 (95% CI 4.54–18.25) | |
| Death by aortic dissection | 21.79 (95% CI 4.62–102.82) | |
| Death by aortic dissection, age below 45 years (subgroup) | 55.59 (95% CI 2.33–1325.69) | |
| Death by heart diseases excluding aortic dissection, ages 46 to 80 years (subgroup) | 7.7 (CI 2.65–22.36) | |
| 0.050.21520Hazard ratio (log scale) |
Death by aortic dissection
- Single largest cause of death in TS, 23% (8/35) of total deaths
Death by cancer or external causes
- Not raised in TS
Median survival time
- 8 years shorter in TS vs controls
Original publication
All-cause mortality and death by aortic dissection in women with Turner syndrome: A national clinical cohort study. Am Heart J. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →