An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled trial (AARDVARK)
Primary result · AAA annual growth rate (modelled)Result — go to the resultDifference 0.08 mm CI −0.50 to 0.65Authors' conclusion
Small AAA growth rates were lower than anticipated, but there was no significant impact of perindopril compared with placebo or placebo and amlodipine, combined despite more effective BP lowering.
Study context
- Population
- Subjects aged ≥55 years with abdominal aortic aneurysms (AAA) diameter 3.0–5.4 cmrandomized 2011–2013
- Participants
- 224 subjects
- Comparison
- Perindopril vs amlodipine vs placebo
- Placebon = 79reference
- Perindopriln = 73
- Amlodipinen = 72
- Primary endpoint
- Aneurysm growth rate (external antero-posterior ultrasound, longitudinal plane), by multi-level modelling
- Follow-up
- Followed 3-6 monthly over 2 years
Methodological detailsthree-arm, multicentre, single-blind, 14 hospitals in England
- Three-arm
- Multicentre
- Single-blind
- 14 hospitals in England
Primary result
AAA annual growth rate (modelled)
Difference
0.08 mm
CI −0.50 to 0.65
Perindopril vs Placebo
difference 0.08 mm (CI −0.50 to 0.65)
As reported in the abstract
Further findings
| Outcome | Placebo | Perindopril | Amlodipine |
|---|---|---|---|
| Change in mid-trial SBP vs baseline · 12 months | mean change 0.5 (SD 14.3) mmHg | mean change −9.5 (SD 13.1) mmHg | mean change −6.7 (SD 12.0) mmHg |
| P vs baseline | P = 0.78 | P < 0.001 | P < 0.001 |
| AAA reaching 5.5 cm diameter and/or elective surgery | 11 events | 10 events | 11 events |
AAA reaching 5.5 cm diameter and/or elective surgery
- Similar numbers in each group
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled trial (AARDVARK). Eur Heart J. Published 1 July 2016. doi:10.
Summarised from the published abstract; every number is checked against it