Arrhythmias & electrophysiology

Anatomic approach to mitral isthmus ablation guided by left atrial intracardiac echocardiography

Heart RhythmPublished Single-arm interventional study

Authors' conclusion

An anatomic approach to mitral isthmus ablation guided by left atrial ICE is feasible and safe, with high acute procedural success.

Study context

Population
Patients undergoing mitral isthmus ablation for mitral annular flutter
Participants
30 patients
Outcome
Bidirectional mitral isthmus block (acute procedural success)
Methodological detailsstepwise approach
  • Stepwise approach

Main finding

As reported in the abstract

Bidirectional mitral isthmus block achieved

29 of 30 cases

97%

Epicardial ablation through the great cardiac vein required

57%

n = 17 patients

Vein of Marshall (VOM) ethanol infusion required

43%

n = 13 patients

Further findings

Additional ablation required

Epicardial ablation through the great cardiac vein
57% (n = 17)
VOM ethanol infusion
43% (n = 13)

Mitral isthmus anatomy by intracardiac echocardiography (ICE)

Mean length
32.5 ± 5.4 mm
Depth
6.0 ± 2.9 mm
Mean thickness
4.5 ± 0.5 mm

Recurrent atrial arrhythmias · follow-up 19 ± 9 months

Patients with recurrence
13
12-month survival free of arrhythmias
60%

Safety

Pericardial effusion
1 case (3%)

Original publication

Anatomic approach to mitral isthmus ablation guided by left atrial intracardiac echocardiography. Heart Rhythm. Published 25 April 2025. doi:10.1016/j.hrthm.2025.01.014

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