Anthracyclines and Biomarkers of Myocardial Injury: The Effect of Remote Ischemic Conditioning
Primary result · TnT (mixed-effects regression, repeated measures)Result — go to the resultMean difference 3.15 ng/L 95% CI −0.04 to 6.33- prematurely halted
Authors' conclusion
TnT and cMyC significantly increased during anthracycline chemotherapy with 81% having a TnT ≥14 ng/L at cycle 6. RIC did not affect the rise in biomarkers, but there was a small increase in early cancer deaths, possibly related to the greater proportion of patients with metastatic disease randomized to the RIC group (54%vs 37%).
Study context
- Population
- Patients receiving anthracycline chemotherapyprematurely halted
- Participants
- 55 patients
- Comparison
- Remote ischemic conditioning (RIC) vs sham at each chemotherapy cycle
- RICn = 28
- Shamn = 27reference
- Primary endpoint
- Troponin T (TnT) during chemotherapy
- Follow-up
- Up to 1 year
Methodological detailssingle-blind, sham-controlled
- Single-blind
- Sham-controlled
Primary result
As reported in the abstract
TnT (mixed-effects regression, repeated measures)
Mean difference
3.15 ng/L
95% CI −0.04 to 6.33
P = 0.053
RICvs Sham
mean difference 3.15 ng/L (95% CI −0.04 to 6.33); P = 0.053
Secondary outcomes
| Outcome | Mean difference (ng/L) (95% CI) | P value | |
|---|---|---|---|
| cMyC (mixed-effects regression, repeated measures) | 4.17 (−0.12 to 8.45) | P = 0.056 | |
| −50510Difference, ng/L (linear scale) |
Events
| Outcome | RIC | Sham | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| MACE and cancer deaths · up to 1 yearMore events with RIC | 11 | 3 | 0.25 (0.07–0.90) | P = 0.034 | |
| Cancer deaths · up to 1 yearMore cancer deaths with RIC | 8 | 1 | 0.21 (0.04–0.95) | P = 0.043 | |
| 0.050.21520Hazard ratio (log scale) |
- Cancer deaths: metastatic disease 54% RIC vs 37% sham
Biomarkers, baseline to cycle 6, all patients
- Median troponin T (TnT) 6 [IQR: 4-9] ng/L to 33 [IQR: 16-36)] ng/L
- P ≤ 0.001
- Median cMyC 3 (IQR: 2-5) ng/L to 47 (IQR: 18-49) ng/L
- P ≤ 0.001
Original publication
Anthracyclines and Biomarkers of Myocardial Injury: The Effect of Remote Ischemic Conditioning. JACC CardioOncol. Published 2 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →