Cardio-oncology & otherMechanistic study
Endothelin Receptor Blocker Reverses Breast Cancer–Induced Cardiac Remodeling
- Mechanistic study
- retrospective clinical assessment
- mouse model of breast cancer
Authors' conclusion
Although our findings should be further examined in other preclinical/clinical models, our data suggest that endothelin receptor blockers may play a role in cardiac health in individuals with breast cancer.
Study context
- Population
- Women with breast cancer before chemotherapy; mouse model of breast cancer
- Participants
- 28 vs 17
- Comparison
- Breast cancer vs Healthy controls
- Breast cancern = 28
- Healthy controlsn = 17reference
Main finding
As reported in the abstract
Cardiac remodeling and cardiac function
- Breast cancer patients before chemotherapy: relative cardiac remodeling and subclinical cardiac dysfunction, associated with activation of the endothelin system
- Mouse model: atrasentan (endothelin receptor blocker) significantly lessened cardiac remodeling and improved cardiac function
Original publication
Endothelin Receptor Blocker Reverses Breast Cancer–Induced Cardiac Remodeling. JACC CardioOncol. Published 2 May 2023. doi:10.1016/j.jaccao.2023.02.004
Summarised from the published abstract; every number is checked against it