Heart failure & cardiomyopathies
Anthropometric Measures and Long-Term Mortality in Non-Ischaemic Heart Failure with Reduced Ejection Fraction: Questioning the Obesity Paradox
Authors' conclusion
In patients with non-ischaemic HFrEF, there was a clear association between greater adiposity and higher long-term mortality.
Study context
- Population
- Patients with non-ischaemic heart failure with reduced ejection fraction (HFrEF) enrolled in DANISH
- Participants
- 1,116 patients
- Comparison
- Alternative anthropometric measures vs body mass index (BMI) for prognosis
- BMI 18.5-24.9 kg/m²n = 363reference
- BMI <18.5 kg/m²n = 24
- BMI ≥35 kg/m²n = 91
- Primary endpoint
- All-cause death (adjusted for prognostic variables incl. natriuretic peptides)
- Follow-up
- Median 9.5 years
Primary result
As reported in the abstract
All-cause death · median 9.5 years
Hazard ratio (95% CI)
BMI ≥35 kg/m²vs BMI 18.5-24.9 kg/m²
1.78(1.28–2.48)
Highest waist-to-height ratio quintilevs Lowest waist-to-height ratio quintile
2.11(1.53–2.92)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CV deathBMI ≥35 kg/m²vs BMI 18.5-24.9 kg/m² | 2.46 (1.69–3.58) | |
| CV deathHighest waist-to-height ratio quintilevs Lowest waist-to-height ratio quintile | 2.17 (1.49–3.15) | |
| 0.20.5125Hazard ratio (log scale) |
CV death
- BMI <18.5 kg/m²: numerically, but not significantly, higher risk
Original publication
Anthropometric Measures and Long-Term Mortality in Non-Ischaemic Heart Failure with Reduced Ejection Fraction: Questioning the Obesity Paradox. Eur J Heart Fail. Published 18 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →