Heart failure & cardiomyopathies
Long-Term Effect of Implantable Cardioverter-defibrillators (ICDs) in Nonischemic Heart Failure With Reduced Ejection Fraction: Extended Follow-Up Analysis of DANISH
Primary result · All-cause deathResult — go to the resultHazard ratio 0.96 95% CI 0.82–1.13Authors' conclusion
In patients with nonischemic HFrEF, during a median follow-up of 13.2 years, primary prevention ICD implantation did not reduce all-cause death, but it did reduce sudden cardiovascular death, and younger individuals appeared to derive a greater benefit.
Study context
- Population
- Nonischemic heart failure with reduced ejection fraction (HFrEF), LVEF ≤35%, NYHA II–III (IV if CRT planned), elevated natriuretic peptides
- Participants
- 1,116 participants
- Comparison
- Primary prevention ICD vs usual clinical care
- Primary endpoint
- All-cause death
- Follow-up
- Median 13.2 years
Methodological detailsextended follow-up, Followed until death or January 31, 2024
- Extended follow-up
- Followed until death or January 31, 2024
Primary result
As reported in the abstract
median 13.2 years (Q1-Q3: 11.6-14.6 years)
Hazard ratio
0.96
95% CI 0.82–1.13
Events by treatment group
ICDvs Control
HR 0.96 (95% CI 0.82–1.13)
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Sudden CV death | 0.54 (0.36–0.80) | |
| Sudden CV death, by age (subgroup)ICDvs Control≤70 years | 0.38 (0.23–0.62) | |
| Sudden CV death, by age (subgroup)ICDvs Control>70 years | 1.27 (0.56–2.89) | |
| 0.20.5125Hazard ratio (log scale) |
- Sudden CV death, by age (subgroup): Pinteraction = 0.01
Other key subgroups, incl. CRT at baseline
- Effect of ICD generally consistent
Original publication
Long-Term Effect of ICDs in Nonischemic Heart Failure With Reduced Ejection Fraction: Extended Follow-Up Analysis of DANISH. J Am Coll Cardiol. Published 22 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →