Valvular & structural heart disease
Aortic Stenosis Intricacies Beyond the Valve: A Bidirectional Mendelian Randomization Study
Authors' conclusion
This comprehensive MR study revealed the causal relationship between genetically predicted CAVS and the increased risk of various CVDs and the causal relationship between hypertension and CAVS risk.
Study context
- Population
- Genetic association data (FinnGen, UK Biobank) on calcific aortic valve stenosis (CAVS) and seven common cardiovascular diseases (CVDs)
- Comparison
- Genetically predicted CAVS vs risk of 7 common CVDs
- Outcome
- Causal association between genetically predicted CAVS and risk of 7 common CVDs
Methodological detailsmeta-analysis of multiple Mendelian randomization (MR) results
- Meta-analysis of multiple MR results
Pooled result
As reported in the abstract
Risk of CVDs with genetically predicted CAVS
Genetically predicted CAVSOdds ratio (95% CI)P value
HF
1.064(1.008–1.123)
P = 0.025Large-artery stroke
1.256(1.112–1.418)
P < 0.001Cardioembolic stroke
1.228(1.117–1.349)
P < 0.001AF
1.100(1.061–1.140)
P < 0.001Further pooled results
Risk of CAVS with genetically predicted hypertension (reverse direction)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Genetically predicted hypertensionFinnGen | 1.170 (1.055–1.297) | P = 0.003 | |
| Genetically predicted hypertensionUK Biobank | 2.456 (1.571–3.840) | P = 8.16 × 10-5 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Aortic Stenosis Intricacies Beyond the Valve: A Bidirectional Mendelian Randomization Study. ESC Heart Fail. Published 13 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →