Valvular & structural heart disease
Ventricular Interaction and Clinical Outcomes in Patients Undergoing Transcatheter Tricuspid Valve Repair
Main findingResult — go to the resultAdjusted hazard ratio 1.66 95% CI 1.04–2.65Authors' conclusion
Ventricular interaction, assessed by LV eccentricity index, was associated with clinical outcomes after TTVr, and its postprocedural improvement was linked to better outcomes.
Study context
- Population
- Patients undergoing transcatheter tricuspid valve repair (TTVr)
- Participants
- 304 patients
- Exposure
- Left ventricular (LV) eccentricity index ≥1.2 vs <1.2
- LV eccentricity index ≥1.2n = 168
- Outcome
- Composite of:
- Mortality
- HF hospitalization
- Follow-up
- Within 1 year
Methodological detailsMedian follow-up 384 days (Q1-Q3: 189-734 days)
- Median follow-up 384 days (Q1-Q3: 189-734 days)
Main finding
As reported in the abstract
Adjusted hazard ratio
1.66
95% CI 1.04–2.65
P = 0.034
LV eccentricity index ≥1.2vs LV eccentricity index <1.2
adjusted HR 1.66 (95% CI 1.04–2.65); P = 0.034
Observational data: associations, not effects.
Further findings
Baseline LV eccentricity index
- Mean LV eccentricity index
- 1.23 ± 0.20
- LV eccentricity index ≥1.2
- 168 of 304 (55.3%)
Improvement of LV eccentricity index to <1.2 at discharge (baseline ≥1.2)
- Improved to <1.2 at discharge
- 83 (49.4%)
- Improvement associated with lower risk of composite outcome vs persistently increased LV eccentricity index
- Smaller RV area, larger left atrial volume index, greater tricuspid regurgitation (TR) reduction and procedural success related to improvement
Original publication
Ventricular Interaction and Clinical Outcomes in Patients Undergoing Transcatheter Tricuspid Valve Repair. JACC Cardiovasc Interv. Published 9 June 2025. doi:10.
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