Valvular & structural heart diseaseCohort study
Aortic stenosis risk and Life’s Crucial 9: the role of proteomics and inflammation
- Prospective cohort study
- UK Biobank
- mediation analysis
Authors' conclusion
Higher LC9 score was associated with reduced aortic stenosis risk. This inverse relationship was significantly mediated by plasma proteomics and inflammatory biomarkers.
Study context
- Population
- UK Biobank participants without aortic stenosis at baseline31,522 with proteomics data
- Participants
- 295,828 participants
- Exposure
- Moderate or high vs low LC9 score
- Outcome
- Incident aortic stenosis
Main finding
As reported in the abstract
Aortic stenosis risk
Each group vs lowHazard ratio (95% CI)
Moderate
0.49(0.44–0.55)
High
0.28(0.23–0.34)
Observational data: associations, not effects.
Further findings
Population attributable risk of low/moderate LC9
- PAR
- 43.6% (95% CI, 34.1-53.0)
Mediation by 549-protein proteomic signature
- Proteomic signature mediated proportion
- 35.9%
- Adrenomedullin
- 20.9%
- Fatty acid-binding protein 4
- 18.6%
- Hepatocyte growth factor
- 17.3%
- Hepatitis A virus cellular receptor 1
- 17.0%
- Growth differentiation factor 15
- 15.8%
Mediation by inflammatory biomarkers
- Mediated proportions (small but significant)
- 1.0 to 5.9%
Original publication
Aortic stenosis risk and Life’s Crucial 9: the role of proteomics and inflammation. Eur J Prev Cardiol. Published 4 August 2025. doi:10.1093/eurjpc/zwaf491
Summarised from the published abstract; every number is checked against it