Valvular & structural heart disease
Quality of Life After Transcatheter Tricuspid Valve Repair: Results from the Tri.FR Trial
Authors' conclusion
Compared with OMT alone, T-TEER resulted in substantial, multidimensional, and sustained improvements in patient-reported quality of life. These findings reinforce the value of T-TEER in managing severe symptomatic TR.
Study context
- Population
- Patients with severe symptomatic tricuspid regurgitation (TR) in the Tri.FR trialrandomized to tricuspid transcatheter edge-to-edge repair (T-TEER) +OMT (n = 152) or OMT alone (n = 148)
- Participants
- 152 vs 148
- Comparison
- T-TEER + OMT vs OMT alone
- T-TEER +OMTn = 152
- OMT alonen = 148
Primary result
As reported in the abstract
Change in Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score (KCCQ-OS) in T-TEER + OMT
KCCQ-OS change at 6 weeks
+17.0 points (95% confidence interval [CI] 13.1-21.5)
KCCQ-OS change at 6 months
+15.9 points
95% CI 11.2–20.6
KCCQ-OS change at 1 year
+18.7 points
95% CI 13.8–23.6
Further findings
| Outcome | Mean between-group difference (points) (95% CI) | |
|---|---|---|
| MLHF total scoreT-TEERvs OMT aloneImproved significantly in the T-TEER group | −8.61 (−12.6 to −4.6) | |
| −20−10010Difference, points (linear scale) |
| Outcome | Estimate |
|---|---|
| KCCQ-OS, mean between-group difference · evident at 6 weeks and sustained for 1 yearIn favour of T-TEER + OMT | mean between-group difference +10.3 points (95% CI 5.6–15.0) |
| MLHF total scoreT-TEER vs OMT alone | physical subscale −3.9 (95% CI −5.9 to −1.9) |
| MLHF total scoreT-TEER vs OMT alone | emotional subscale −2.2 (95% CI −3.4 to −1.0) |
Original publication
Quality of Life After Transcatheter Tricuspid Valve Repair: Results from the Tri.FR Trial. ESC Heart Fail. Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →