Valvular & structural heart disease
Aortic valve neocuspidization using the Ozaki technique: A meta-analysis of reconstructed patient-level data
Authors' conclusion
The midterm outcomes of the Ozaki procedure are excellent in terms of hemodynamics, survival, and freedom from reoperation.
Study context
- Population
- Adults and children undergoing aortic valve neocuspidization (Ozaki reconstruction)
- Participants
- 1,891 adults22 studies
- Outcome
- Freedom from reoperation (reconstructed patient-level data)
- Follow-up
- 1, 3 and 5 years
Methodological detailssingle-arm, PubMed and Cochrane searched up to November 13, 2021; individual patient data reconstructed from Kaplan-Meier curves
- Single-arm
- PubMed and Cochrane searched up to November 13, 2021; individual patient data reconstructed from Kaplan-Meier curves
Pooled result
As reported in the abstract
In-hospital mortality
0.7%
95% CI 0.1–1.7
Late mortality (mean follow-up 38.1 ± 23.8 months)
1.9%
Further pooled results
Procedural characteristics
- Mean age at surgery (± SD), years
- 43.2 ± 24.5
- Mean age, adults
- 65 ± 12.3 years
- Mean age, pediatric
- 12.3 ± 3.8 years
- Indication AS
- 46.4%, 95% CI 34.1-58.6
- Mean cross-clamp time
- 106.8 ± 24.8 minutes
- Mean cardiopulmonary bypass time
- 135.2 ± 35.1 minutes
Reoperations due to infective endocarditis
- Share of reoperations due to infective endocarditis
- 51.5%, 95% CI 18.3-84.0
Safety
Permanent pacemaker implantation
- Permanent pacemaker
- 0.7% (95% CI 0.4-1.2)
Endocarditis
- Risk of endocarditis per patient per year
- 0.5%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Aortic valve neocuspidization using the Ozaki technique: A meta-analysis of reconstructed patient-level data. Am Heart J. Published 14 September 2022. doi:10.
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