Heart failure & cardiomyopathies
Chronic Kidney Disease, Heart Failure, and Adverse Cardiac Remodeling in Older Adults: The ARIC Study
Authors' conclusion
Mild to moderate kidney dysfunction and damage associate with incident HF and adverse cardiac remodeling in late-life.
Study context
- Population
- Older adults free of heart failure (HF) at ARIC visit 5 (2011–2013)2,313 with echocardiograms
- Participants
- 5,170 adults
- Exposure
- Lower estimated glomerular filtration rate (eGFR) and higher urine albumin-to-creatinine ratio (UACR) vs higher eGFR and lower UACR
- Outcome
- Incident HF, HFrEF and HFpEF; changes in cardiac structure and function
- Follow-up
- Through 2019
Methodological detailsmultivariable Cox proportional hazards models, multivariable linear regression models
- Multivariable Cox proportional hazards models
- Multivariable linear regression models
Main finding
As reported in the abstract
- Lower eGFR and higher UACR associated with greater risk of any HF, heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) (fully adjusted)
- Lower eGFR associated with larger increases in LV end-diastolic volume index and worsening of diastolic measures
- UACR not associated with changes in cardiac structure or function
Observational data: associations, not effects.
Further findings
Baseline characteristics · visit 5
- Mean age, years
- 76 ± 5
- Men
- 2,225 (43%)
- Mean eGFR, mL/min/1.73 m²
- 66 ± 18
- Median UACR, mg/g (25th, 75th percentile)
- 11 (6, 22)
Original publication
Chronic Kidney Disease, Heart Failure, and Adverse Cardiac Remodeling in Older Adults: The ARIC Study. JACC Heart Fail. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →