Kidney function and risk of heart failure in older adults: findings from a prospective cohort study
Authors' conclusion
In this large cohort of older adults, albuminuria was associated with increased risk of HF outcomes, supporting its role in HF risk assessment. Low eGFR was also linked to higher risk of HHF, HF death and the HF composite outcome. Associations with high eGFR were not conclusive and should be considered hypothesis-generating.
Study context
- Population
- Community-dwelling older adults from the ASPirin in Reducing Events in the Elderly (ASPREE) trial and ASPREE eXTension observational study with complete baseline data on albuminuria and estimated glomerular filtration rate (eGFR)participants with complete baseline data on albuminuria and eGFR
- Participants
- 17,834 adults
- Exposure
- Participants with albuminuria compared with those with no albuminuria; eGFR levels
- Outcome
- First hospitalisation for HF; death due to HF
- Follow-up
- Median 8.6 years
Methodological detailsASPirin in Reducing Events in the Elderly (ASPREE) clinical trial and follow-up ASPREE eXTension observational study, Cox models adjusting for potential confounders
- ASPirin in Reducing Events in the Elderly (ASPREE) clinical trial and follow-up ASPREE eXTension observational study
- Cox models adjusting for potential confounders
Main finding
As reported in the abstract
First hospitalisation for heart failure (HF)
354
1.98%
Died due to HF
147
0.82%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HHF, HF death and combined HF outcome by albuminuriaAlbuminuria vs no albuminuria · HHF | 1.47 (1.12–1.92) | |
| HHF, HF death and combined HF outcome by albuminuriaAlbuminuria vs no albuminuria · HF death | 1.55 (1.04–2.33) | |
| HHF, HF death and combined HF outcome by albuminuriaAlbuminuria vs no albuminuria · combined HF outcome | 1.33 (1.05–1.70) | |
| Re-admission due to HF by albuminuriaAlbuminuria vs no albuminuria · although there was no difference in risk of HF death | 1.30 (1.03–1.65) | |
| 0.512Hazard ratio (log scale) |
HHF, HF death and HF composite outcome by eGFR
- U-shaped relationship with increased risk at both low (eg, <60 mL/min/1.73 m²) and high (eg, >90 mL/min/1.73 m²) eGFR levels
- The association at high eGFR was not statistically significant and may reflect residual confounding
HF re-admission by eGFR
- No association was observed between eGFR and HF re-admission
Original publication
Kidney function and risk of heart failure in older adults: findings from a prospective cohort study. Heart. Published 22 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →