Heart failure & cardiomyopathies
NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study
Authors' conclusion
Higher concentrations of NT-proBNP and hs-cTnI, but not hs-cTnT, were associated with greater declines in left ventricular function over ≈7 years in late life independently of traditional cardiovascular risk factors.
Study context
- Population
- Older adults free of overt CVD with echocardiography at ARIC visits 5 (2011–2013) and 7 (2018–2019)
- Participants
- 2,006 adults
- Exposure
- Baseline NT-proBNP, high-sensitivity cardiac troponin T (hs-cTnT) and hs-cTnI concentrations and ≈7-year change in LV structure and function
- Outcome
- Change in LV structure and function between visits 5 and 7
- Follow-up
- ≈7-year change
Methodological detailsmultivariable linear regression, restricted cubic splines, Adjusted for age, sex, race, BMI, smoking, DM, hypertension, renal function at visit 5; BP and heart rate at both visits; baseline value of the echocardiographic parameter
- Multivariable linear regression
- Restricted cubic splines
- Adjusted for age, sex, race, BMI, smoking, DM, hypertension, renal function at visit 5; BP and heart rate at both visits; baseline value of the echocardiographic parameter
Main finding
As reported in the abstract
≈7 years
- Elevated baseline hs-cTnT not significantly associated with 7-year changes in cardiac structure, systolic or diastolic function
- all P>0.05
Observational data: associations, not effects.
Further findings
Baseline characteristics and biomarker concentrations at visit 5
- Mean±SD age
- 74±4 years
- Women
- 61%
- Black adults
- 23%
- Median (25th-75th percentile) NT-proBNP
- 87 ng/L (50-157 ng/L)
- Median (25th-75th percentile) hs-cTnT
- 9 ng/L (6-12 ng/L)
- Median (25th-75th percentile) hs-cTnI
- 2.6 ng/L (1.9-3.9 ng/L)
Original publication
NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study. Circulation. Published 24 September 2024. doi:10.
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