Heart failure & cardiomyopathies
Arrhythmic Risk Stratification According to Late Gadolinium Enhancement (LGE) Corridors and Genetics in Nonischemic Dilated Cardiomyopathy
Authors' conclusion
LGE corridors and HRGs provide additive value for arrhythmic risk stratification in patients with nonischemic dilated cardiomyopathy.
Study context
- Population
- Patients with nonischemic dilated cardiomyopathy who had undergone genetic testing and CMR, 22 European centres
- Participants
- 925 patients
- Exposure
- LGE corridors and high-risk genotypes as predictors of major ventricular arrhythmic events
- LGE corridorsn = 160
- HRGn = 119
- Outcome
- Major ventricular arrhythmic events (MVA)
- Follow-up
- Median 5.4 years
Methodological detailsconsecutive patients, 22 European centres, competing-risk analysis
- Consecutive patients
- 22 European centres
- Competing-risk analysis
Main finding
As reported in the abstract
MVA · median follow-up 5.4 years (IQR 3.3-7.7)
Subdistribution hazard ratio (95% CI)P value
Number of LGE corridors
1.25(1.11–1.42)
P < 0.001HRG
2.28(1.32–3.96)
P = 0.003- Patients with an MVA
- 95 (10.3%)
Observational data: associations, not effects.
Further findings
| Outcome | Stepwise algorithm | LVEF ≤35% | P value |
|---|---|---|---|
| Prediction of MVA: stepwise algorithm (LGE, ≥4 LGE corridors, HRG) vs LVEF ≤35%-based guideline classification · 5 years | P = 0.001 | ||
| Time-dependent AUC | 0.72 (95% CI, 0.65-0.78) | 0.57 (95% CI, 0.51-0.64) |
- Prediction of MVA: stepwise algorithm (LGE, ≥4 LGE corridors, HRG) vs LVEF ≤35%-based guideline classification — Progressive increase in arrhythmic risk across categories
- Gray test P<0.001
Prediction of MVA: stepwise algorithm (LGE, ≥4 LGE corridors, HRG) vs LVEF ≤35%-based guideline classification · 5 years
- Optimal cutoff of ≥4 LGE corridors predicted MVA
Original publication
Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy. Circulation. Published 8 September 2026. doi:10.
Summarised from the published abstract; every number is checked against it