Heart failure & cardiomyopathies
Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy
Main finding · Primary end pointResult — go to the resultAdjusted hazard ratio 1.48 95% CI 1.12–1.95Authors' conclusion
The genetic architecture and sex are critical predictors of left ventricular reverse remodeling and long-term prognosis in DCM.
Study context
- Population
- Patients with dilated cardiomyopathy (DCM) who had undergone genetic testing; 7 genotype groups (cytoskeletal/Z-disk, desmosomal, nuclear envelope, motor sarcomeric, TTN, other genetic, genotype negative)510 (30%) with (likely) pathogenic variant
- Participants
- 1,716 patients
- Exposure
- Men vs women, by genotype group
- Menn = 1,130
- Outcome
- Major adverse events (mortality, HF hospitalization, heart transplantation, malignant ventricular arrhythmias); LV reverse remodeling
- Follow-up
- Median 6.7 years
Methodological detailsmulticentre, 4 international referral centres
- Multicentre
- 4 international referral centres
Main finding
Primary end point
Adjusted hazard ratio
1.48
95% CI 1.12–1.95
P = 0.02
Events by group
Men with (likely) pathogenic variant vs Genotype-negative women
adjusted HR 1.48 (95% CI 1.12–1.95); P = 0.02
As reported in the abstract
- Prognosis varied by gene in men
- log-rank P<0.0001
- Prognosis did not vary by gene in women
- log-rank P=0.1
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Malignant ventricular arrhythmias | 1.83 (1.16–2.88) | P = 0.009 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
LV reverse remodeling in women, by genotype vs genotype negative
- TTN: highest rate
- P = 0.003
- Desmosomal: lowest rate
- P = 0.04
- Gene-dependent in women
Original publication
Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy. Circ Heart Fail. Published 24 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it